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8811 Biochemical and Molecular Foundations of Clinical Diagnosis - Six-year degree in Medicine


Center
Faculty of Medicine and Odontology
Departament
Biochemistry and Molecular Biology
Lecturers in charge
Sin datos cargados
Met. Docent
Seminarys,theorics and practics classes.
Met. Avaluació
Final exam.
Bibliografia
Norman Lavin. Manual de Endocrinología y Metabolismo Tomo I y II. Salvat
Scriver, Beaudet, Valle, Sky. The Metabolic and Molecular Basis of Inherited Disease. Mc Graw-Hill
Cohen, Lewis, Alberti, Denman. The Metabolic and Molecular Basis of Acquired Disease. Baillière-Tindall
Norbert W. Tietz. Clinical Guide to Laboratory Test. Saunders Company
José Manuel Gonzalez de Buitrago. Patología Molecular. MacGraw-Hill
Paola Timiras. Bases Fisologicas del envejecimiento y geriatria. Masson
Continguts

Theory Program
PART I. BIOCHEMICAL AND MOLECULAR BASES OF PATHOLOGY:
1. Molecular bases of illness
2. Free radicals and oxidative stress. Molecular mechanisms and Physiopathologicial Implications
3. Cell death. Degeneration, aging
4. Alterations in cell growth (neoplasia, discrasia and aplasia)
5. Inflammation
6. Molecular bases of clinical toxicology
7. Molecular bases of genetic illnesses
8. Alterations in recognition mechanisms and in the effectiveness of the immune system: hypersensitivity, auto-immunity and immuno-deficiency.

PART II. ALTERATIONS IN THE CELLULAR METABOLISM
9. Metabolism of carbohydrates
10. Metabolism of amino acids
11. Metabolism of lipids and lipo-proteins
12. Metabolism of purines and pirimidines
13. Mitochondrial disease
14. Nutritional pathology
15. Metabolism of iron

PART III. ALTERATIONS IN ORGANS AND TISSUES: THE NEXUS BETWEEN
CLINICAL MANIFESTATIONS AND ANALYTIC DATA
16. Plasmatic proteins
17. Serum enzymes and their diagnostic value
18. Abnormal metabolites in urine
19. The hepatic and biliar function
20. Alterations in the
Objetius
Objectives:
1. To introduce the biochemical and molecular bases of the most relevant situations of metabolic alteration.
2. To introduce the biochemical and molecular aspects underlying the most relevant diagnostic procedures of the clinical analysis laboratory.
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