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12619 Biology of Cell Differentiation - Five-year degree in Biology

Center

Faculty of Biological Sciences

Departament

Cellular Biology and Parasitology

Lecturers in charge

Sin datos cargados

Met. Docent

Non-obligatory theory classes and obligatory practical classes.

Met. Avaluació

see attached document

Bibliografia

Gilbert, S.F. (2000)-Developmental Biology. 6th Ed. Sinauer Associates, Inc.Publ
Alberts et al. (1994) Molecular Biology of the cell. 3rd Ed. Garland Pub.
Stein, C.S. & Lian, J.B. (1992) Molecular and cellular aproaches to the control of proliferation and differentiation. Academic Press, Inc.
De Pomerai (1990) An introduction to the molecular biology of animal development. Cambridge Univ. Press.
Shankland, M. & Macagno E.R. (1992) Determinants of neuronal identity. Academic Press Inc.
Steeves. A.T. & Sussex, I.M.(1989) Patterns in plant development. Second edition. Cambridge University Press

Continguts

SYLLABUS:
Cellular and molecular bases of the cellular proliferation and differentiation. Introduction to the study of the Cellular Differentiation Biology. Models and study methods. The cellular cycle. Phases and regulation. The sexual reproduction: meiosis. Phases and biological meaning. Cellular and molecular mechanisms of the animal fecundation and first phases of the embryonic development. Development of the cellular specificity. Genic control of the cellular differentiation. Cellular differentiation, renovation and death. Characteristic of the differentiated state in mammals. The cellular differentiated state. Ageing and cellular death. Regulation of the cellular differentiation. Transduction of signs. Signalling molecules and their receptors. Role of the cellular surface receptors. Intracellular signal transduction pathways. Cytoskeleton and signalling. Signalling in development and differentiation. Cellular proliferation and differentiation abnormalities: Cancer. Cancer development and causes.Tumour viruses. Oncogenes. Tumour suppressive genes.

OBJETIVES:
The aim of this subject is to provide the students with an integrated knowledge of the different cellular and molecular mechanisms implied in the cellular proliferation and differention phenomena. We will focus on the study of the cellular cycle and its regulation, fecundation and proliferation, and differentiation processes during the embryonic development and its genic control, as well as the

Objetius

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